Trial
Generation 100
Research Observatory
Evidence Update
Current evidence
Generation 100 randomized 1,567 older adults to high-intensity interval training, moderate continuous training or active guideline controls for five years. Mortality was 4.5% in the combined supervised-exercise groups versus 4.7% in controls; a mortality advantage was not demonstrated.
What changed
Preserves the active comparator and notes VO2peak—not verified VO2max for all—alongside the primary outcome.
What did not change
The exploratory HIIT mortality trend is not confirmed superiority or proof of equivalence.
Why it matters
One trial's physiological and mortality publications/readouts should be reviewed together.
Main limitation
Healthy volunteer selection, crossover and adherence reduce separation.
Next proof
Trials that preserve exposure contrast and prespecify clinical/physiological links.
Summary
Generation 100 randomized 1,567 older adults for five years; combined exercise mortality was 4.5% versus 4.7% in guideline controls.
Intelligence Take
One trial's physiological and mortality publications/readouts should be reviewed together.
Limitations
Healthy volunteer selection, crossover and adherence reduce separation.