Biomarker
Circulating taurine
Research Observatory
Evidence Update
Current evidence
Circulating taurine is not supported here as a universal monotonic aging marker.
What changed
Adds longitudinal/cross-sectional discordance, the step-test exception and non-monotonic frailty findings.
What did not change
Association does not measure metabolic flux or predict response to supplementation.
Why it matters
A marker concept should not inherit an intervention's animal lifespan claim.
Main limitation
Cohort/phenotype differences, diet unmeasured in the frailty study, unresolved subgroup denominators.
Next proof
External phenotype-specific replication with dietary and longitudinal characterization.
Summary
Circulating taurine is not supported here as a universal monotonic aging marker.
Intelligence Take
A marker concept should not inherit an intervention's animal lifespan claim.
Limitations
Cohort/phenotype differences, diet unmeasured in the frailty study, unresolved subgroup denominators.