Intervention
Multivitamin-mineral supplementation
Research Observatory
Evidence Update
Current evidence
Daily multivitamin-mineral supplementation was compared with placebo for cognitive performance in COSMOS ancillary studies; the pooled analysis included 5,203 nonoverlapping participants from one programme. COSMOS ancillary studies support a small multivitamin cognitive-performance signal, not demonstrated dementia prevention or three independent trial replications.
What changed
COSMOS pooled ancillary results suggest a small cognitive-performance benefit; they do not demonstrate dementia prevention or three independent programme replications.
What did not change
Small score shifts or age-equivalent calibrations are not demonstrated rejuvenation.
Why it matters
Separates ingredient attribution, endpoint hierarchy and participant denominators.
Main limitation
Selected subsets, small score differences, different assessment modalities. Cross-sectional age-equivalent calculations are not years of biological rejuvenation.
Next proof
Independent programme with clinically meaningful function/dementia outcomes and durable follow-up.
Summary
Daily multivitamin-mineral supplementation was compared with placebo for cognitive performance in COSMOS ancillary studies; the pooled analysis included 5,203 nonoverlapping participants from one programme. COSMOS ancillary studies support a small multivitamin cognitive-performance signal, not demonstrated dementia prevention or three independent trial replications.
Intelligence Take
Separates ingredient attribution, endpoint hierarchy and participant denominators.
Limitations
Selected subsets, small score differences, different assessment modalities. Cross-sectional age-equivalent calculations are not years of biological rejuvenation.