Trial
LIFE
Research Observatory
Evidence Update
Current evidence
LIFE randomized 1,635 vulnerable older adults to structured physical activity—walking, resistance and flexibility training—or health education. Major mobility disability occurred in 30.1% with physical activity versus 35.5% with health education.
What changed
Adds the primary clinical endpoint, HR .82 with 95% CI .69–.98, and the serious-adverse-event comparison.
What did not change
The trial did not establish longer life or reversal of aging.
Why it matters
Loss of ability to walk 400 m is an interpretable patient-relevant endpoint.
Main limitation
Selected function-limited older volunteers; this projection is bounded to verified abstract/indexed findings.
Next proof
Population-specific replication and implementation studies.
Summary
LIFE randomized 1,635 vulnerable older adults; major mobility disability occurred in 30.1% with structured activity versus 35.5% with health education.
Intelligence Take
Loss of ability to walk 400 m is an interpretable patient-relevant endpoint.
Limitations
Selected function-limited older volunteers; this projection is bounded to verified abstract/indexed findings.