Trial
TAME: Trial Design, Endpoints, and Status Tracker
Source Summary
2 reviewed sources across 1 evidence layers.
- Official status sources2
Trial Snapshot
Executive Summary
Tracks TAME's proposed design, composite endpoint, funding, registration and launch status without treating plans as results.
Why It Matters
TAME is an influential geroscience trial proposal, but design, registration, launch status and results must remain separate claims.
Trial Design
| Design field | Registered / reported value | Source | Limitation |
|---|---|---|---|
| Population | Proposed older adults without diabetes | AFAR and peer-reviewed design papers | Proposed design may change before registration |
| Intervention | Metformin versus placebo | Peer-reviewed design papers | Not evidence of efficacy |
Endpoint and Readout Map
| Endpoint / readout | Category | Source | What it supports | Limitation |
|---|---|---|---|---|
| Composite of major age-related outcomes | Proposed clinical composite | Peer-reviewed design papers | The intended geroscience trial question | No registered protocol or result at cutoff |
Results and Publication Context
No TAME results
The approved sources do not support describing TAME as initiated or reporting TAME outcomes.
Timeline / Milestones
- Status verified
Source Posture
Official status
AFAR describes launch funding as still needed; registry search found no TAME-specific record.
Evidence / Claim Boundary
Design is not evidence
A proposed randomized design does not establish metformin efficacy, healthspan benefit or lifespan benefit.
What This Can Support
Supported
TAME is designed to test a composite clinical-outcome geroscience hypothesis.
What This Does Not Prove
Not established
Metformin is not established as an anti-aging treatment.
Detailed Sources
View detailed source table
Official status sources
| Source | Type | Supports | Limitation | Link |
|---|---|---|---|---|
| AFAR TAME overview | Official program page | Current program description and funding/launch posture | Sponsor description is not efficacy evidence | Open source |
| ClinicalTrials.gov search | Registry search | No exact TAME registry record found at cutoff | Search absence is not regulatory rejection | Open registry search |
Confidence / Methodology
Editorial status
Editorial review complete; source freshness checked
Evidence separation
Status is verified against the approved official-source cutoff. Proposed design is not treated as an active protocol or result.
Last reviewed
2026-08-02